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Urine collection from rats orally treated with UTIRose
In spite we checked all the peaks, we used anthocyanins as first markers of Utirose compounds in the urinary tract pathway, especially :cyanidin-3-0-sambudioside (gossypicyanin)
cyanidin-3-0-glucoside
delphinidin- 3-0-sambudioside (hibiscin)
delphinidin- 3-0-glucoside
Conclusion : HPLC of UTIrose™ and
urine from rats with single ingestion of UTIrose™ (525 nm):
After a single ingestion, UTIrose™ shows a low bioavailability, which
means that molecular compounds are eliminated by urinary
excretion. UTIrose™ is available in urinary tract where its
antimicrobial activity could be efficient.Because all these molecules are not available as analytical standards, cyanidin-3-0-glucoside is used for quantification and calculation of recovery level of all anthocyanins in the urine of the rat. The first observation is that urines from rats with a single ingestion of Utirose content anthocyanins, whereas urine a blank rat without treatment shows of course no anthocyanins. Compounds of Utirose were recovered in urine in the intact glycosidic form.
After a single oral administration, Utirose quickly appeared in urine (2h). Anthocyanins are used as markers of Utirose compounds.